PerformUp

• To reduce triglyceride levels in adults with severe hypertriglyceridemia (≥500 mg/dL).
• To reduce the risk of cardiovascular events such as myocardial infarction and stroke in adult patients with triglyceride levels ≥150 mg/dL and high risk for cardiovascular events.

• Oral, with food
• Swallow whole; do not break, crush, dissolve, or chew.

Warnings & Precautions

Talk to your doctor or pharmacist before you take this medicine if you have any of the following:

• Allergy to fish or shellfish.
• Liver problems
• Problems with irregular heartbeat (atrial fibrillation or flutter).
• If you take an anticoagulant medicine (which prevents blood from clotting), medicines that inhibit platelets in the blood or are at risk of bleeding.

Pregnancy & Breastfeeding

• If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
• Icosapent ethyl is not recommended during pregnancy and breast-feeding unless your doctor advises you to take it.

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including the following: (In case of concomitant use of the following medications, patient monitoring by a physician is recommended, and no adjustment to the treatment regimen is required.)

• Anticoagulants: e.g., Heparin, Warfarin, Apixaban, and Rivaroxaban
• Ibrutinib (Antineoplastic)
• Antiplatelets: e.g., Aspirin, Clopidogrel, Ticagrelor, and Prasugrel

Side effects with an incidence greater than 10% include:

• Hemorrhage

If you take more PerformUp® than you should
If you accidentally take more capsules than your doctor has prescribed, contact your doctor or pharmacist for advice.

If you forget to take PerformUp®

• If you miss a dose, take it as soon as you remember.
• If you missed taking the medicine for a whole day, just take your next scheduled dose.
• Do not take a double dose to make up for the forgotten dose.

Hypersensitivity (e.g., anaphylactic reaction) to icosapent ethyl or any component of the formulation.

• Keep PerformUp® at a temperature between 15-30°C and away from heat, light, and moisture.
• Keep PerformUp® in the original container.
• Keep this medicine out of the sight and reach of children.
• Do not use this medicine after the expiry date.

PerformUp® is supplied as a bottle containing 60 softgel capsules.