What is Xabano (Apixaban)?
Xabano (apixaban) blocks the activity of certain clotting substances in the blood. Xabano is used to lower the risk of stroke or a blood clot in people with a heart rhythm disorder called atrial fibrillation. Xabano reduces the risk of forming a blood clot in the legs and lungs of people who have just had hip or knee replacement surgery.
Xabano treats blood clots in the veins of your legs (DVT – deep vein thrombosis) or lungs (pulmonary embolism), and reduce the risk of them occurring again.
Warnings
Xabano increases your risk of severe or fatal bleeding, especially if you take certain medicines at the same time (including some over-the-counter medicines). It is very important to tell your doctor about all medicines you have recently used.
Call your doctor at once if you have signs of bleeding such as: swelling, pain, feeling very weak or dizzy, bleeding gums, nosebleeds, heavy menstrual periods or abnormal vaginal bleeding, blood in your urine, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds, or any bleeding that will not stop.
Xabano should be stopped 24-48 hours prior to any surgery, invasive procedure, or dental work. Tell your surgeon if you are taking Xabano.
Xabano can cause a very serious blood clot around your spinal cord that can lead to long-term or permanent paralysis. This type of blood clot can occur during a spinal tap or spinal anesthesia (epidural), especially if you have a genetic spinal defect, if you use a spinal catheter, if you’ve had spinal surgery or repeated spinal taps, or if you use drugs that can affect blood clotting.
Get emergency medical help if you have symptoms of a spinal cord blood clot such as back pain, numbness or muscle weakness in your lower body, or loss of bladder or bowel control.
Do not stop taking Xabano unless your doctor tells you to. Stopping suddenly can increase your risk of blood clot or stroke.
You should not take Xabano if you are allergic to apixaban, or if you have active bleeding from a surgery, injury, or other cause.
Tell your doctor if you have an artificial heart valve, or if you have ever had:
Xabano can cause a very serious blood clot around your spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural).
This type of blood clot could cause long-term paralysis, and may be more likely to occur if:
*Taking Xabano may increase the risk of bleeding while you are pregnant or during your delivery. Tell your doctor if you are pregnant or plan to become pregnant.
*Do not breastfeed.
How should I take Xabano?
Take Xabano exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
You may take Xabano with or without food.
If you cannot swallow a tablet whole, crush it and mix with water, apple juice, or applesauce. Swallow the mixture right away without chewing.
A crushed tablet mixture may also be given through a nasogastric (NG) feeding tube. Read and carefully follow any Instructions for Use provided with your medicine.
*Xabano can make it easier for you to bleed, even from a minor injury. Seek medical attention if you have bleeding that will not stop.
*Tell your doctor if you have a planned surgery or dental work. You may need to stop taking Xabano for a short time.
*Do not stop taking xabano unless your doctor tells you to.
*If you stop taking Xabano for any reason, your doctor may prescribe another medicine to prevent blood clots.
Storage condition: Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose on the same day you remember it. Take your next dose at the regular time and stay on your twice-daily schedule. Do not take two doses at one time.
Get your prescription refilled before you run out of xabano completely.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help center.
What should I avoid while taking Xabano?
Avoid activities that may increase your risk of bleeding or injury. Use extra care while shaving or brushing your teeth.
Side effects:
Get emergency medical help if you have signs of an allergic reaction to Eliquis: hives; chest pain, wheezing, difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat.
Also seek emergency medical attention if you have symptoms of a spinal blood clot such as tingling, numbness, or muscle weakness especially in your legs and feet.
Call your doctor at once if you have:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
What other drugs will affect Xabano?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many other drugs (including some over-the-counter medicines) can increase your risk of bleeding or blood clots. Tell your doctor about all medicines you have recently used, especially:
This list is not complete and many other drugs may interact with apixaban. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Dosing information
Usual Adult of Xabano Dose for Deep Vein Thrombosis — Prophylaxis:
DEEP VEIN THROMBOSIS (DVT) PROPHYLAXIS FOLLOWING HIP OR KNEE REPLACEMENT SURGERY:
2.5 mg orally twice a day
Duration of therapy:
-Hip replacement: 35 days
-Knee replacement: 12 days
Comments: The initial dose should be taken 12 to 24 hours after surgery.
Use: Prophylaxis of DVT, which may lead to pulmonary embolism (PE), in patients who have undergone hip or knee replacement surgery.
RECURRENT DVT AND PE RISK REDUCTION:
2.5 mg orally twice a day.
Usual Adult Dose of Eliquis for Deep Vein Thrombosis Prophylaxis after Hip Replacement Surgery:
DEEP VEIN THROMBOSIS (DVT) PROPHYLAXIS FOLLOWING HIP OR KNEE REPLACEMENT SURGERY:
2.5 mg orally twice a day
Duration of therapy:
-Hip replacement: 35 days
-Knee replacement: 12 days
Comments: The initial dose should be taken 12 to 24 hours after surgery.
Use: Prophylaxis of DVT, which may lead to pulmonary embolism (PE), in patients who have undergone hip or knee replacement surgery.
RECURRENT DVT AND PE RISK REDUCTION:
2.5 mg orally twice a day.
Adult Dose for of Eliquis Deep Vein Thrombosis Prophylaxis after Knee Replacement Surgery:
DEEP VEIN THROMBOSIS (DVT) PROPHYLAXIS FOLLOWING HIP OR KNEE REPLACEMENT SURGERY:
2.5 mg orally twice a day
Duration of therapy:
-Hip replacement: 35 days
-Knee replacement: 12 days
Comments: The initial dose should be taken 12 to 24 hours after surgery.
Use: Prophylaxis of DVT, which may lead to pulmonary embolism (PE), in patients who have undergone hip or knee replacement surgery.
RECURRENT DVT AND PE RISK REDUCTION:
2.5 mg orally twice a day.
Usual Adult Dose of Eliquis for Prevention of Thromboembolism in Atrial Fibrillation:
5 mg orally 2 times a day
Use: Reduction of risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.
Usual Adult Dose of Eliquis for Thromboembolic Stroke Prophylaxis:
5 mg orally 2 times a day
Use: Reduction of risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.
Adult Dose for Deep Vein Thrombosis:
Initial dose: 10 mg orally 2 times a day for 7 days
Maintenance dose: 5 mg orally 2 times a day
Use: Treatment of deep vein thrombosis and pulmonary embolism.
Usual Adult Dose for Pulmonary Embolism:
Initial dose: 10 mg orally 2 times a day for 7 days
Maintenance dose: 5 mg orally 2 times a day
Use: Treatment of deep vein thrombosis and pulmonary embolism.