What is Nanojade (deferasirox)?

Nanojade binds to iron and removes it from the bloodstream.
Deferasirox is used to treat iron overload caused by blood transfusions in adults and children at least 2 years old. Deferasirox is also used to treat chronic iron overload syndrome caused by a genetic blood disorder in adults and children who are at least 10 years old.

Warnings

You should not use deferasirox if you have severe kidney or liver disease, advanced cancer, a blood cell or bone marrow disorder, or low levels of platelets in your blood.

Deferasirox can harm your liver or kidneys. Call your doctor at once if you have swelling, shortness of breath, pain in your upper stomach, loss of appetite, little or no urinating, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Deferasirox may also cause stomach or intestinal bleeding. Call your doctor at once if you have symptoms of stomach bleeding such as bloody or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

You should not use this medication if you are allergic to it, or if you have:

• severe liver or kidney disease
• advanced cancer
• a bone marrow disorder
• low levels of platelets in your blood

Tell your doctor if you have ever had:

• kidney disease
• liver disease
• anemia (low red blood cells)
• cancer (especially blood cell cancer such as leukemia)
• a stomach ulcer
• stomach or intestinal bleeding
• vision or hearing problems
• a weak immune system caused by disease (such as cancer, HIV, or AIDS), or by receiving steroids, chemotherapy, or radiation

*It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

*Deferasirox can make birth control pills less effective. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy.

*You should not breast-feed while you are taking deferasirox.

How should I take deferasirox?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Take deferasirox at the same time every day.

You may take Nanojade on an empty stomach or with a small low-fat meal.

Swallow the nanojade tablet whole with a full glass of water. If you cannot swallow the tablet whole, you may crush the tablet and mix it with yogurt, applesauce, or other soft food.

After mixing a crushed tablet or sprinkles with soft food, swallow the mixture right away without chewing. Do not save it for later use.

You may need frequent blood tests. Your kidney or liver function may also need to be checked every 6 months, and you may need a liver biopsy.

Storage condition: Store at room temperature, away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help center.

What should I avoid while taking Nanojade?

Do not use other iron-chelating medicines such as deferoxamine (Desferal), unless your doctor has told you to.

Do not take antacids that contain aluminum, such as Amphojel, Gaviscon, Maalox, Mi-Acid, Mylanta, Rulox, and others.

Deferasirox may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Side effects:

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Stop using deferasirox and call your doctor at once if you have:

• problems with vision or hearing
• kidney problems–little or no urination, swelling in your feet or ankles, feeling tired or short of breath
• liver problems–nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
• low blood cell counts–fever, chills, mouth sores, skin sores, pale skin, easy bruising, unusual bleeding, cold hands and feet, feeling light-headed or short of breath
• signs of stomach bleeding–bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds

Serious side effects may be more likely in older adults.

Common side effects may include:

• nausea, vomiting, stomach pain
• diarrhea
• skin rash

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

What other drugs will affect deferasirox?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Many drugs can affect deferasirox. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.