What is Arnoxa (Posaconazole)?

Posaconazole is an antifungal medicine that is used to treat or prevent fungal infections that can spread throughout your body. posaconazole is sometimes used in people with weak immune systems caused by certain treatments such as chemotherapy or stem cell transplantation.

Posaconazole injection or delayed-release tablets are used to treat infections in adults and children at least 13 years old.

To prevent infections, posaconazole is given in the following ways:

  • The injection is used in adults and children at least 2 years old.


Tell your doctor about all your other medicines. Some drugs should not be used with posaconazole.

Before taking this medicine:

You should not use posaconazole if you are allergic to posaconazole or similar antifungals such as fluconazole, itraconazole, ketoconazole, or voriconazole.

Some drugs should not be used with posaconazole. Your treatment plan may change if you also use:

  • midazolam
  • pimozide
  • quinidine
  • sirolimus
  • cholesterol lowering medicines–atorvastatin, lovastatin, simvastatin, and others
  • ergot medicine–dihydroergotamine, ergotamine, ergonovine, or methylergonovine

Tell your doctor if you have ever had:

  • heart problems
  • blood circulation problems
  • liver or kidney disease
  • an electrolyte imbalance (such as high or low blood levels of calcium, potassium, magnesium, or sodium)

May harm an unborn baby. Tell your doctor if you are pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

How should I use posaconazole?

Posaconazole injection is given in a vein and must be given slowly over 30 to 90 minutes.

Prepare an injection only when you are ready to give it. Be sure you understand how to properly mix this medicine with a liquid (diluent) and how to store the mixture. Call your pharmacist if the medicine has particles in it.

Keep using this medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication. Posaconazole will not treat a viral infection (flu or a common cold).

Call your doctor if you have ongoing vomiting or diarrhea. Posaconazole may not work as well while during this time.

You may need frequent medical tests.

Storage condition

Store posaconazole injection in the refrigerator. Take the vial out of the refrigerator and let it reach room temperature before mixing with a diluent. If you cannot give the injection right away, place the mixed medicine in the refrigerator and use it within 24 hours. Throw away a vial, bottle, or IV bag after one use even if there is still medicine left inside. Do not reuse a needle or syringe. Place them in a puncture-proof “sharps” container and dispose of it following state or local laws. Keep out of the reach of children and pets.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if you take a high dose of this drug?

Contact the emergency room or poison control center.

side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out)
  • swelling in an arm or leg
  • shortness of breath
  • liver problems–nausea, vomiting, itching, feeling tired, jaundice (yellowing of the skin or eyes)
  • signs of an electrolyte imbalance–increased thirst or urination, constipation, muscle pain or weakness, numbness or tingling, confusion, feeling jittery, irregular heartbeats

Common side effects may include:

  • diarrhea, nausea, vomiting;
  • low potassium (an electrolyte);
  • headache
  • fever
  • cough

What other drugs will affect posaconazole?

Posaconazole can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Tell your doctor about all your current medicines. Many drugs can affect posaconazole, especially:

  • cimetidine
  • cyclosporine
  • esomeprazole
  • rifabutin
  • phenytoin
  • tacrolimus
  • certain cancer medicines–vinblastine, vincristine, vinorelbine
  • medicine to treat HIV–atazanavir, efavirenz, fosamprenavir, ritonavir

This list is not complete and many other drugs may affect posaconazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.